Folding for binding or binding for folding?
نویسنده
چکیده
A number of proteins are (partially) unstructured at physiological conditions and assume a well-defined three-dimensional structure only upon binding to another protein or macromolecular complex. Numerous examples have been found especially among proteins involved in regulatory functions in eukaryotic cells. Recent computer simulations by Verkhivker et al. have yielded an atomic detail picture of the folding of p27 and its concomitant binding to the phosphorylated cyclin A-cyclin dependent kinase 2 (Cdk2).
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عنوان ژورنال:
- Trends in biotechnology
دوره 21 10 شماره
صفحات -
تاریخ انتشار 2003